Development of Metamaterial-Based Biosensor for Biomedical Applications
DOI:
https://doi.org/10.4314/njtd.v22i1.3282Keywords:
Biosensor, Equivalent circuit, Metamaterial, Split rectangular resonator, Sensitivity, Breast cancer detectionAbstract
Breast cancer is one of the most commonly diagnosed cancers among women. For fast and effective treatment of breast cancer, early detection is inevitable. Material characterization or detection is essential for identifying the specific type of material suited for a given application, whether it is a solid, semi-solid, liquid, or powdered sample. This study presents a biosensor that utilizes metamaterials to detect cancerous cells through their electrical properties for clinical diagnostics. The design features a rectangular patch microstrip-fed grounded planar structure with a split ring resonator (SRR) loaded at two ports. The SRR is constructed utilizing its inductive and capacitive resonance characteristics, rendering it an appropriate sensing option. Using the four different breast cancer cells as material detection units and air as a reference, detection is performed. The evaluation of the sensor's performance involves the analysis of four distinct breast cancer cells: HS578, MCF-7, MDA-MB-231, and MDA-2. The RLC equivalent circuit has been introduced to enhance the comprehension of the sensor's functionality. The measurement outcomes of the prototype sensor aligned closely with simulated results derived from the computer simulation technology suite (CST) and Advanced design system (ADS). The biosensor can be suitably integrated into clinical diagnostic tools for the early detection and classification of breast cancer. This will potentially enable timely detection of cancer and precise treatment of breast cancer.
References
A. Buragohan, A. T. T. Mostako, and G. S. Das (2021). Lowcost CSRR based sensor for determination of dielectric constant of liquid samples, IEEE Sensors J., 21 (24): Art no 24.
A. Ebrahimi, J. Scott, and K. Ghorbani, (2018). Differential sensor using microstrip lines loaded with two split ring resonator, IEEE Sensors J. 18 (14): 5780-5793.
A. H. Jabire, A. Ghaffar, Y. Faouri, (2024). Frequency and pattern reconfigurable CPW-Fed MIMO antenna with multiband and wideband characteristics, IEEE Access, 12, 120165-120180.
C. G. Juan, E.Bronchalo, B. Potelon, et al., (2019). Concentration measurement of microliter volume glucose solution using $Q$ factor of microwave sensors, IEEE Trans. Instrum. Meas., 68 (9):
D. Jithin, M. I. Hussein, F. Awwad, and R. Irtini, (2016). Dielectric characterization of breast cancer cell lines using microwave, In proc. ICEDSA Ras Alkhaimah, 1-4.
D. M. Pozar, (2017). Microwave Engineering 4th Edition, New Delhi, Wiley India.
E. L. Chuma and T. Rasmussen, (2022). Metamaterial-based sensor integrating microwave dielectric and near-infrared spectroscopy technique for substrate evaluation, IEEE Sensors J. 22, 19308.
E. L. Chuma, Y. Iano, L. L. B. Roger et al. (2022). Novelty sensor for detection of wear particles in oil using integrated microwave metamaterial resonator with neodymium magnets, IEEE Sensors J., 22, 10508.
E. L. Chuma, Y. Lano, G. Fontgalland, and L. L. B. Roger, (2018): Microwave sensor for liquid dielectric characterization based on metamaterial complementary split ring resonator, IEEE Sensors J. 18 (24): 9978-9983.
Fauri Y. Ahmad S. Naseer S. Alhammami K., et al. (2022). Compact super-wideband frequency diversity hexagonal shaped monopole antenna with switchable rejection band," IEEE Access, 10, 42321-42333.
G. Juan, E. Bronchalo, B. Potelon, C. Quendo, E. Avila-Navarro, and J. M. Sabater-Navarro (2019). Concentration measurement of microliter-volume water–glucose solutions using Q factor of microwave sensors, IEEE Trans. Instrum. Meas., 68 (7): 621–634.
G. Galindo-Romera, J. Carnerero-Cano, J. MartÃnez-MartÃnez, and F. Herraiz-MartÃnez, (2017). An IoT reader for wireless passive electromagnetic sensors, Sensors, 17 (4): p. 693.
G. Ggugliandolo, G. Vermiglio, G. Cutioneo, et al. (2023). Development, characterization and circuit modeling of inkjet printer couple ring resonator for application in biological samples, IEEE Trans. Instrum. Meas., 72, 1.
Hong X. San Y. Cheng G and Juan C, (2022). A dual scale CSRRs based sensor for dielectric characterization of solid materials, IEEE Sensor Letters, vol. 6 (12), 3502704, 2022.
J. Carnerero-Cano, G. Galindo-Romera, J. J. Martinez-Martinez, and F. J. Herraiz-Martinez, (2018). A contactless dielectric constant sensing system based on a split-ring resonator-loaded monopole, IEEE Sensors J., 18 (11): 4491–4502.
J. K. Park, C. Jang, G. H. Yun, et al., (2020). Sensitive relative humidity monitoring sensor based on microwave active resonator, IEEE Access, 8: 166283-166293.
J. Naqui and F. Martin, (2014). Angular displacement and velocity sensor based on electric LC (ELC) loaded microstrip lines, IEEE Sensors J. 14 (4): 939-840.
K. Masrakin, S. Z. Ibrahim, H. A. Rahim, et al., (2023). Microstrip sensor based on ring resonator coupled with double square split ring resonator for solid material permittivity characterization, Micromachines, 14 (4): 790.
K. T. Muhammad Shafi, A.K. Jha and M. J. Akhtar, (2017). Improved planar resonant RF sensor for retrieval of permittivity and permeability of materials, IEEE Sensors J. 17 (7), 5479-5486.
M. A. H. Ansari, A. K. Jha, and M. J. Akhtar, (2015). Design and application of CSRR based planar sensor for noninvasive measurement of complex permittivity, IEEE Sensors J. 15 (12): 7181-7189.
M. I. Hussein, F. Awwad, D. Jithin, H. El Hasasna, K. Athamneh and R. Iratni (2019). Characterization of breast cancer-specific dielectric signature in vitro using the open-ended coaxial probe technique from 200 MHz to 13.6 GHz. Scientific Reports, 9 (1): 4681.
M. S. Boybay, and O. M. Ramahi, (2012). Material characterization using complementary split ring resonator, IEEE Trans. Instrum. Meas. 61 (11), 3039-3046.
M. U. Memon, A. Salim, H. Jeong, and S. Lim, (2020). IEEE Trans. Instrum. Meas., 69 (4), 1344-1352.
P. K. Varshney, A. Kapoor, and M. J Akhtar, (2021). Highly sensitive ELC resonator based differential sensor, IEEE Trans. Instrum. Meas. 70 1-10.
P. K. Varshney, A. Sharma and M. J. Akhtar, (2020). Exploration of adulteration in some food materials using high sensitivity configuration of electric LC resonator sensor, Int. J. RF Microw Comput Aided Eng., 30 (2): 22045.
P. Yazhmaee and H. Minoofar, (2014). Electric LC resonator as a microwave for oil sensing, Electronic Letters, 50 (16): 1147-1148
R. Yadav and P. N. Patel (2018). Characterization of high-frequency dielectric laminates using a scanning probe based on EBG structure. IEEE Trans. Instrum. Meas. 67 (1): 107–115.
S. Jiang, G. Liu, M. Wang, Y. Wu and J. Zhou, (2023). Design of high sensitivity microfluidic sensor based on CSRR with interdigital structure, IEEE Sensors J., 1-1.
W. J. Wu, W. S. Zhao, D. W. Wang et al. (2021). A temperature compensated differential microstrip sensor for microfluidic applications, IEEE Sensors J. 21 (21): 24075 – 24083.
W. S. U., B. S. Cook, and M. M. Tentzens, (2016). Additively manufactured microfluidic based peel and replace RF sensor for wearable applications, IEEE Trans. Microw. Theory and Techn., 64 (6): 1928-1936.
W. Withayachumnankul, K. Jaruwongrungsee, A. Tuantranont, et al., (2013). Metamaterial based microfluidic sensor for dielectric characterization, Sensors and Actuators A: Physical, 189, 233-237.
Xinyue Song, Sen Yan and Juan Chen, (2023). A design of metamaterial inspired resonator for multi-frequency fluidic sensors, IEEE Microw. Wirel. Tech. Lett., 33(1): 94–97.
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